A new series of Schiff bases derived from o- vanillin and dapsone: Synthesis, spectral, thermal and antibacterial studies
Dr. V. A. Sadafale
, Dr. P. R. Mandlik
Dapsone, Schiff base, Metal complexes, Antibacterial activity
A novel Schiff base ligand was prepared by the condensation of o- vanillin and dapsone, and then metal complexes of Co(II), Ni(II), Cr(III) and VO(IV) were synthesized. The metal complexes were characterized and investigated by physical and spectral techniques, namely, elemental analysis, melting point, conductivity, 1H NMR, IR, UV-Vis spectra, ESR, and mass spectrometry measurements. They were further analyzed by thermal technique (TGA/DTA) to gain better insight about the thermal stability and kinetic properties of the complexes. Thermal data revealed high thermal stability and non-spontaneous nature of the decomposition steps. The Freeman-Carroll and Sharp-Wentworth method was applied to extract thermodynamic parameters to explain the kinetic behavior. The molar conductance values were relatively low, showing their non-electrolytic nature. The electronic and ESR spectra of metal complexes provides information about geometry of the complexes and are in good agreement with proposed square planar geometry of Co(II) and Ni(II), octahedral for Cr(III) and square pyramidal for VO(IV) complexes. The antibacterial activity of all the compounds was screened against four bacterial pathogens, namely, E. coli, S. aureus, P. aeruginosa and K. pneumoniae. It has been found that the Schiff base and its metal complexes showed significant antimicrobial activity.
"A new series of Schiff bases derived from o- vanillin and dapsone: Synthesis, spectral, thermal and antibacterial studies", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.6, Issue 7, page no.69 - 76, July-2021, Available :https://ijsdr.org/papers/IJSDR2107015.pdf
Volume 6
Issue 7,
July-2021
Pages : 69 - 76
Paper Reg. ID: IJSDR_193457
Published Paper Id: IJSDR2107015
Downloads: 000347327
Research Area: Chemistry
Country: Dattapur Dhamangaon, Maharashtra, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
