Welcome to IJSDR UGC CARE norms ugc approved journal norms IJRTI Research Journal | ISSN : 2455-2631
IJSDR
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
International Peer Reviewed & Refereed Journals, Open Access Journal
ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
Scholarly open access journals, Peer-reviewed, and Refereed Journals, Impact factor 8.15 (Calculate by google scholar and Semantic Scholar | AI-Powered Research Tool) , Multidisciplinary, Monthly, Indexing in all major database & Metadata, Citation Generator, Digital Object Identifier(DOI)

Issue: August 2022

Volume 7 | Issue 8

Impact factor: 8.15

Click Here For more Info

Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter

Copyright Infringement Claims
Indexing Partner
Published Paper Details
Paper Title: PARP inhibitors in various cancers
Authors Name: Nirav Parmar
Unique Id: IJSDR2106043
Published In: Volume 6 Issue 6, June-2021
Abstract: Poly (ADP-ribose) polymerase which is component of DNA repair processes, especially base excision repair (BER). SSBs in DNA are repaired by BER. SSBs aggregate and create double stand breaks when BER is suppressed, which inhibits PARP. Alternative repair processes, including as nonhomologous end joining and homologous recombination (HR), become more important as the frequency of DSBs increases. Patients with a faulty HR, such as BRCA deficient cell lines, are highly sensitive to BER pathway disruption. PARP inhibitors destroy cancer cells in BRCA mutant cancer cell lines more effectively than normal cancer cell lines. PARPi also enhance cytotoxicity by limiting repair in the context of SSB-generating chemotherapies. In a clinical environment, these two ideas were put to the test. Because of its shown efficacy as a single agent in BRCA1 or BRCA2 related ovarian or breast malignancies, as well as in conjugation with chemotherapy in triple negative breast cancer, interest in this class of drugs has risen in recent years. This article addresses the mechanism of PARPi and their involvement in different Cancers.
Keywords: PARP, BER, SSB, DSB, BRCA, Cytotoxicity, chemotherapy, Homologous recombination.
Cite Article: "PARP inhibitors in various cancers", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 6, page no.273 - 279, June-2021, Available :http://www.ijsdr.org/papers/IJSDR2106043.pdf
Downloads: 000101746
Publication Details: Published Paper ID: IJSDR2106043
Registration ID:193441
Published In: Volume 6 Issue 6, June-2021
DOI (Digital Object Identifier):
Page No: 273 - 279
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

Click Here to Download This Article

Article Preview

Click here for Article Preview







Major Indexing from www.ijsdr.org
Google Scholar ResearcherID Thomson Reuters Mendeley : reference manager Academia.edu
arXiv.org : cornell university library Research Gate CiteSeerX DOAJ : Directory of Open Access Journals
DRJI Index Copernicus International Scribd DocStoc

Track Paper
Important Links
Conference Proposal
ISSN
DOI (A digital object identifier)


Providing A digital object identifier by DOI
How to GET DOI and Hard Copy Related
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
Creative Commons License
This material is Open Knowledge
This material is Open Data
This material is Open Content
Social Media
IJSDR

Indexing Partner