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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Issue: August 2022

Volume 7 | Issue 8

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Paper Title: PARP inhibitors in various cancers
Authors Name: Nirav Parmar
Unique Id: IJSDR2106043
Published In: Volume 6 Issue 6, June-2021
Abstract: Poly (ADP-ribose) polymerase which is component of DNA repair processes, especially base excision repair (BER). SSBs in DNA are repaired by BER. SSBs aggregate and create double stand breaks when BER is suppressed, which inhibits PARP. Alternative repair processes, including as nonhomologous end joining and homologous recombination (HR), become more important as the frequency of DSBs increases. Patients with a faulty HR, such as BRCA deficient cell lines, are highly sensitive to BER pathway disruption. PARP inhibitors destroy cancer cells in BRCA mutant cancer cell lines more effectively than normal cancer cell lines. PARPi also enhance cytotoxicity by limiting repair in the context of SSB-generating chemotherapies. In a clinical environment, these two ideas were put to the test. Because of its shown efficacy as a single agent in BRCA1 or BRCA2 related ovarian or breast malignancies, as well as in conjugation with chemotherapy in triple negative breast cancer, interest in this class of drugs has risen in recent years. This article addresses the mechanism of PARPi and their involvement in different Cancers.
Keywords: PARP, BER, SSB, DSB, BRCA, Cytotoxicity, chemotherapy, Homologous recombination.
Cite Article: "PARP inhibitors in various cancers", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 6, page no.273 - 279, June-2021, Available :http://www.ijsdr.org/papers/IJSDR2106043.pdf
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Publication Details: Published Paper ID: IJSDR2106043
Registration ID:193441
Published In: Volume 6 Issue 6, June-2021
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Page No: 273 - 279
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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