|
INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
Imp Links for Author
Imp Links for Reviewer
Research Area
Subscribe IJSDR
Visitor Counter
Copyright Infringement Claims
Indexing Partner
|
Published Paper Details
|
|
| Paper Title: | FORMULATION AND EVALUATION OF TOPICAL ANTIFUNGAL GEL OF FLUCONAZOLE USING ALOE VERA GEL |
| Authors Name: | KM Shiva , Suraj Mandal , Sanjeev Kumar |
| Unique Id: | IJSDR2101028 |
| Published In: | Volume 6 Issue 1, January-2021 |
| Abstract: | The Present research is based on developing Topical gel formulation of fluconazole with the help of natural Aloe Vera gel. Fluconazole is a Triazoles derivative and used to prevent and treat candidiasis. Taking fluconazole by oral administration is not considered appropriate as it has many side effects. Commercially fluconazole topical gel preparations are available in market which is formulated with the help of synthetic polymer. Thus, this formulation is made for better patient compliance and to reduce the dose of drug and to avoid side effect like liver damage kidney damage and safe in pregnancy. Methods: The gel was formulated by changing the synthetic polymer. Various formulations like (F1, F2, F3, F4, F5 and F6) were developed by using natural polymer aloe Vera. The formulation was evaluated for % yield, spread ability, extrudability, wash ability and viscosity in vitro release study, Skin irritation study, stability testing. Result: Carried out viscosity studies of various formulations evident that formulation F1 was better to compare to other. From among all the developed formulation F1 show better drug diffusion, good rheological properties, pH of F5formulation is sufficient to treat the skin infection. Result indicated that the concentration of aloe Vera significantly affected drug release and rheological properties of the gel. Conclusion: it was calculated that formulation F1 was the best formulation among this formulation. Hence formulation F1 should be further developed for scale-up to industrial production. |
| Keywords: | : Anti-fungal activity, Fluconazole, Aloe-vera, |
| Cite Article: | "FORMULATION AND EVALUATION OF TOPICAL ANTIFUNGAL GEL OF FLUCONAZOLE USING ALOE VERA GEL", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.6, Issue 1, page no.187 - 193, January-2021, Available :http://www.ijsdr.org/papers/IJSDR2101028.pdf |
| Downloads: | 000337072 |
| Publication Details: | Published Paper ID: IJSDR2101028 Registration ID:192848 Published In: Volume 6 Issue 1, January-2021 DOI (Digital Object Identifier): Page No: 187 - 193 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
|
Click Here to Download This Article |
|
| Article Preview | |
|
|
|
Major Indexing from www.ijsdr.org
| Google Scholar | ResearcherID Thomson Reuters | Mendeley : reference manager | Academia.edu |
| arXiv.org : cornell university library | Research Gate | CiteSeerX | DOAJ : Directory of Open Access Journals |
| DRJI | Index Copernicus International | Scribd | DocStoc |
Track Paper
Important Links
Conference Proposal
ISSN
 |
 |
DOI (A digital object identifier)
  Providing A digital object identifier by DOI How to GET DOI and Hard Copy Related |
Open Access License Policy
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License
|
 |
 |
 |
Social Media
Indexing Partner |
|||
| Copyright © 2024 - All Rights Reserved - IJSDR | |||
Facebook Twitter Instagram LinkedIn