Impact of microbiota on pathophysiology of graft-versus-host disease post allogeneic hematopoietic stem cell transplantation: a review

Angelina D. Mecwan , Dr. Chirag Desai

allogeneic hematopoietic stem cell transplantation, graft-versus-host disease, microbiota, enterococcus, transplantation

Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially lifesaving treatment of patients with hematopoietic malignancies. Graft-versus-host disease (GVHD) becomes a main contributor to mortality as the T-cells from the donor recognize the host tissue as foreign. The intestinal microbiota remains severely affected after allo-HSCT resulting in loss of microbiota diversity and growth of opportunistic pathogens belonging to the Enterococcus genus. The disruption of the microflora along with occurrence of harmful pathogens results in high mortality from GVHD, organ failure and infection after allo-HSCT treatment. According to the recent studies and their findings, injury in the microbiota was globally observed after allo-HSCT treatment. Enterococcus colonization in the intestine is promoted by dietary habits like consumption of lactose post transplantation, making it a source of various bloodstream infections and accelerating GVHD. Recent reports suggest Enterococcus expansion in the presence of lactose, which is associated with an increase in GVHD related post allo-HSCT mortality. Moreover, severity of GVHD is also linked with changes in the fecal and plasma microbiota-derived molecules. In this review, we discuss the role of microbiota diversity from clinical and mouse microbiota research contributing to the development of post-transplant complications and domination of the Enterococcus pathogen which would be an advancement to find whether modification of the microbiota may reduce chances of GVHD.

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"Impact of microbiota on pathophysiology of graft-versus-host disease post allogeneic hematopoietic stem cell transplantation: a review", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.5, Issue 12, page no.71 - 73, December-2020, Available :https://ijsdr.org/papers/IJSDR2012010.pdf

Volume 5 Issue 12, December-2020

Pages : 71 - 73

Paper Reg. ID: IJSDR_192742

Published Paper Id: IJSDR2012010

Downloads: 000347187

Research Area: Biological Science

Country: Valsad, Gujarat, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR2012010

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR2012010

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

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