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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Impact of microbiota on pathophysiology of graft-versus-host disease post allogeneic hematopoietic stem cell transplantation: a review |
| Authors Name: | Angelina D. Mecwan , Dr. Chirag Desai |
| Unique Id: | IJSDR2012010 |
| Published In: | Volume 5 Issue 12, December-2020 |
| Abstract: | Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially lifesaving treatment of patients with hematopoietic malignancies. Graft-versus-host disease (GVHD) becomes a main contributor to mortality as the T-cells from the donor recognize the host tissue as foreign. The intestinal microbiota remains severely affected after allo-HSCT resulting in loss of microbiota diversity and growth of opportunistic pathogens belonging to the Enterococcus genus. The disruption of the microflora along with occurrence of harmful pathogens results in high mortality from GVHD, organ failure and infection after allo-HSCT treatment. According to the recent studies and their findings, injury in the microbiota was globally observed after allo-HSCT treatment. Enterococcus colonization in the intestine is promoted by dietary habits like consumption of lactose post transplantation, making it a source of various bloodstream infections and accelerating GVHD. Recent reports suggest Enterococcus expansion in the presence of lactose, which is associated with an increase in GVHD related post allo-HSCT mortality. Moreover, severity of GVHD is also linked with changes in the fecal and plasma microbiota-derived molecules. In this review, we discuss the role of microbiota diversity from clinical and mouse microbiota research contributing to the development of post-transplant complications and domination of the Enterococcus pathogen which would be an advancement to find whether modification of the microbiota may reduce chances of GVHD. |
| Keywords: | allogeneic hematopoietic stem cell transplantation, graft-versus-host disease, microbiota, enterococcus, transplantation |
| Cite Article: | "Impact of microbiota on pathophysiology of graft-versus-host disease post allogeneic hematopoietic stem cell transplantation: a review", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 12, page no.71 - 73, December-2020, Available :http://www.ijsdr.org/papers/IJSDR2012010.pdf |
| Downloads: | 000337067 |
| Publication Details: | Published Paper ID: IJSDR2012010 Registration ID:192742 Published In: Volume 5 Issue 12, December-2020 DOI (Digital Object Identifier): Page No: 71 - 73 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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