INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
In the conventional drug delivery system achieving and maintaining concentration of drug within the therapeutic range, frequent dosing is required which results into see - saw pattern of the drug levels. To overcome these problems, controlled drug delivery systems were introduced. The objective of the present study was to develop Gliclazide gastroretentive drug delivery system in order to achieve an extended retention in the upper GIT which may result in enhance the absorption and improve the bioavailability. The tablets were prepared by applying polymers like carbopol974P, eudragit RSPO, eudragit RLPO, eudragit RS100 and combination formulations like of HPMCK100LV with EC and HPMCK100LV with HPMCK4M. The results were satisfactory which clearly manifests the necessity of combining different class of polymers to get an acceptable release profile. It can be suggested that formulations containing combinations of HPMCK100LV and EC (B10), HPMCK100LV and HPMCK4M (B25) can be employed successfully for the development of sustained release tablets of gliclazide. The formulations containing combinations of HPMCK100LV and EC (B10), HPMCK100LV and HPMCK4M (B25) can be employed successfully for the development of sustained release tablets of gliclazide. Also these formulations showed comparable release with that of marketed product M1. Formulations B10 and B25 were found to be stable when short-term stability study was carried out at 400C/75%RH.
"Preparation and Evaluation of Gastroretentive drug delivery system of Gliclazide", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 10, page no.29 - 35, October-2020, Available :http://www.ijsdr.org/papers/IJSDR2010006.pdf
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Publication Details:
Published Paper ID: IJSDR2010006
Registration ID:192575
Published In: Volume 5 Issue 10, October-2020
DOI (Digital Object Identifier):
Page No: 29 - 35
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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