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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Rp-hplc method development and validation for simultaneous estimation of lopinavir and ritonavir in bulk and tablet dosage form |
| Authors Name: | Althaf.Shaik , Reshma.Shaik , Prachet.Pinnamaneni |
| Unique Id: | IJSDR2009046 |
| Published In: | Volume 5 Issue 9, September-2020 |
| Abstract: | A simple, Accurate, precise method was developed for the simultaneous estimation of the ritonavir and lopinavir in bulk and tablet dosage form.Chromatogram was run through schimadzu C18 (250 x 4.6 mm, 5m).Mobile phase containing Acetonitrile :phosphate Buffer taken in the ratio 60:40v/v was pumped through column at a flow rate of 1.2 ml/min. Buffer used in this method was 0.1% OPA buffer. Optimized wavelength selected was 226 nm. Retention time of ritonavir and lopinavir were found to be 6.428min and 7.325 min. %RSD of the ritonavir and lopinavir were and found to be 0.7 and 0.8 respectively. %Recovery was obtained as 100.16% and 98.96% for ritonavir and lopinavir.LOD, LOQ values obtained from regression equations of ritonavir and lopinavir were 4.08, 3.49 and 12.3, 10.5 respectively.Regression equation of ritonavir is y =13739x+11111, and y = 3713x+3510 of lopinavir.Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular quality control test in Industries. |
| Keywords: | Ritonavir,lopinavir,Method development, RP-HPLC. |
| Cite Article: | "Rp-hplc method development and validation for simultaneous estimation of lopinavir and ritonavir in bulk and tablet dosage form", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 9, page no.277 - 289, September-2020, Available :http://www.ijsdr.org/papers/IJSDR2009046.pdf |
| Downloads: | 000337211 |
| Publication Details: | Published Paper ID: IJSDR2009046 Registration ID:192463 Published In: Volume 5 Issue 9, September-2020 DOI (Digital Object Identifier): Page No: 277 - 289 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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