INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
The Aim of the present study, the ethanolic extract of root of Oroxylum Indicum was assessed for its protective effect towards carbon tetrachloride (CCl4)-induced hepatic damage in Albino Wistar rats. Oroxylum Indicum extract’s hepatoprotective activity was explored by calculating hepatic marker enzyme levels of the rats: alanine aminotransferase (ALT) and aspartate aminotransferase (AST) together with the oxidative stress mediator levels as nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), glutathione peroxidase (GPx), superoxide dismutase (SOD) and also TLC profile of petroleum ether, chloroform, ethyl acetate, ethanol and water extract. Results showed that the use of the extract at concentrations of 200 and 400 mg/kg showed a substantial reduction in ALT and AST serum levels as well as a considerable decrease in oxidative stress mediators NO, MDA and an increase in antioxidant enzyme levels GSH, GPx, and SOD. These biochemical results were reinforced by examining the histopathological features of the liver. Thus, the Oroxylum Indicum root demonstrated marked protective impact of the liver that likely due to the synergistic action of its flavonoids content.
"Evaluation of Hepatoprotective activity of Oroxylum Indicum root ethanolic extract", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 7, page no.206 - 211, July-2020, Available :http://www.ijsdr.org/papers/IJSDR2007025.pdf
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Publication Details:
Published Paper ID: IJSDR2007025
Registration ID:192083
Published In: Volume 5 Issue 7, July-2020
DOI (Digital Object Identifier):
Page No: 206 - 211
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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