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Paper Title: Preparation and Evaluation of Omeprazole sodium Lozenges by Heating and Congealing Technique
Authors Name: Aman Bais , Sachin Ghayal , Rahul Rajge , Vedanshu Malviya
Unique Id: IJSDR2006043
Published In: Volume 5 Issue 6, June-2020
Abstract: The present work is focused on development of candy lozenges which serves the purpose of increasing the bioavailability. To check if there are any interactions between the drugs and various components of formulation, FT-IR was performed and there were no interactions seen. The lozenges of Omeprazole sodium were prepared by using different polymers like HPMC K4M and sodium alginate with different ratios. The average weight of the prepared lozenges was found to be in the range of 2.16±0.006 to 3.08±0.004 gram, the percent friability was found to be in the range of 1.86±0.008 to 2.14±0.003, the hardness was found to be in the range of 10.15±0.004 to 12.27±0.003 kg/cm2, the disintegration time was found to be in the range of 23.35±0.007 to 24.25±0.0012 minutes, the percent drug content was found to be 96.5±0.006 to 99.4±0.005, and the percent moisture content was found to be in the range of 0.5±0.015 to 0.8±0.026. From all the evaluation parameters FL2 was considered as the optimized formulation. The in-vitro drug release was carried out in phosphate buffer of pH 6.8 and was found that the drug release depends on the concentration of the polymer. The drug release kinetics of optimized formulation FL2 fitted best to the zero order kinetics with the mechanism of Korsmeyer-peppas drug release. The stability study of the optimized formulation shows no significant changes in the product. In the view of above findings, effect of polymers like, HPMC K4M shows better result in heat congealing technique for preparation of lozenges.
Keywords: Lozenges, Omeprazole sodium , HPMC K4M, Chitosan Hydrochloride, Sodium Alginate, Heat Congealing Technique.
Cite Article: "Preparation and Evaluation of Omeprazole sodium Lozenges by Heating and Congealing Technique", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 6, page no.262 - 268, June-2020, Available :http://www.ijsdr.org/papers/IJSDR2006043.pdf
Downloads: 000201507
Publication Details: Published Paper ID: IJSDR2006043
Registration ID:191929
Published In: Volume 5 Issue 6, June-2020
DOI (Digital Object Identifier):
Page No: 262 - 268
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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