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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Issue: January 2023

Volume 8 | Issue 1

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Paper Title: Preparation and Characterization of Benidipine Hydrochloride Microballoons
Authors Name: Juili Satao , Pallavi Wadaskar , Aman Bais , Sushant Bhamburkar , Vedanshu Malviya
Unique Id: IJSDR2006030
Published In: Volume 5 Issue 6, June-2020
Abstract: The present aim of this study was to develop the GRDDS (Gastro Retentive Drug Delivery System) to increase the floating time as well as to maintain the drug content in the blood for a longer period of time. The microballoons of Benidipine Hydrochloride were prepared by Emulsion Solvent Diffusion using Eudragit RS100 and Eudragit S100 as the coating Polymer. The micromeretics property of the microballoons shows satisfactory results. The prepared batches of the microballoons were then tested for the various parameters in which the microballoons showed good drug entrapment value of 77.28 %, the % buoyancy was found to be 84.25%, the % yield was found to be 90.41. The % Cumulative Drug Release profile showed that the prepared microballoons have a sustained drug release actions of more than 24 hours as the drug release percentage was 83.51% in 24 hours. 1:1 mixture of ethanol and bThe floating time of the microballoons was found to be more than 8 hours. The batch B2 was concluded as optimum because it showed the maximum drug content, more floating time and the more sustained release effect.
Keywords: Microballoons, Benidipine Hydrochloride, Eudragit RS100, Eudragit S100.
Cite Article: "Preparation and Characterization of Benidipine Hydrochloride Microballoons", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 6, page no.176 - 181, June-2020, Available :http://www.ijsdr.org/papers/IJSDR2006030.pdf
Downloads: 000201506
Publication Details: Published Paper ID: IJSDR2006030
Registration ID:191920
Published In: Volume 5 Issue 6, June-2020
DOI (Digital Object Identifier):
Page No: 176 - 181
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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