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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Development and Validation of RP-HPLC and UV-Spectrophotometric Absorptivity Method for Simultaneous Estimation of Cyclobenzaprine hydrochloride and Aceclofenac in Pharmaceutical dosage form |
| Authors Name: | Annasaheb Sanjay Gaikwad , Monika Namdev Madibone , Jeevan R Rajguru , Prashant B Jadhav |
| Unique Id: | IJSDR2004056 |
| Published In: | Volume 5 Issue 4, April-2020 |
| Abstract: | The objective of present research is to develop a simple, sensitive, linear, precise and accurate RP-HPLC and UV-Spectrophotometric method for simultaneous estimation of Cyclobenzaprine hydrochloride and Aceclofenac in bulk and tablet formulation as developed and validated. UV-Spectrophotometric method Calibration plot were linear R2 =0.9996 over the concentration range 1-5µg/ml for Cyclobenzaprine hydrochloride, R²= 0.9995 for the Aceclofenac 13-65µg/ml. And Chromatographic conditions used are stationary phase Inertsil ODS column (250 × 4.6 mm×5µ) (5µm particle size) the mobile phase Methanol: 10mm KH2PO4 Buffer (Ph-3) (70:30) and flow rate was maintained 0.9ml/min, detection wavelength was 220nm. The retention times were 4.7min and 2.9 min for Cyclobenzaprine hydrochloride and Aceclofenac respectively. Calibration plot were linear R2 = 0.9996 over the concentration range 3-15µg/ml for Cyclobenzaprine hydrochloride, R2 = 0.9994 for the Aceclofenac 40-200µg/ml. No interference from any component of pharmaceutical dosage form was observed. The proposed method has been validated as per ICH guidelines, validation studies revealed that method id specific, rapid, reliable and reproducible. The developed method successfully employed for routine quality control analysis in the combined pharmaceutical dosage form. |
| Keywords: | Cyclobenzaprine hydrochloride and Aceclofenac, UV- Spectrophotometric, RP-HPLC Method. |
| Cite Article: | "Development and Validation of RP-HPLC and UV-Spectrophotometric Absorptivity Method for Simultaneous Estimation of Cyclobenzaprine hydrochloride and Aceclofenac in Pharmaceutical dosage form", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 4, page no.320 - 329, April-2020, Available :http://www.ijsdr.org/papers/IJSDR2004056.pdf |
| Downloads: | 000337212 |
| Publication Details: | Published Paper ID: IJSDR2004056 Registration ID:191659 Published In: Volume 5 Issue 4, April-2020 DOI (Digital Object Identifier): Page No: 320 - 329 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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