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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Screening of Oncogenic Signaling Pathways and Therapeutic Application of Monoclonal Antibodies in Breast Cancer |
| Authors Name: | Alka Patel , Shivani , Vinod Kumar Gupta |
| Unique Id: | IJSDR2003020 |
| Published In: | Volume 5 Issue 3, March-2020 |
| Abstract: | Breast cancer is one of the most common diagnosed cancers in the women worldwide. Due to the pervasiveness of breast cancer mortality rate increases. There has been a variety of factors involved in breast cancer progression such as pathological causes, role of different molecular and biochemical marker, genetic mutation, gene expression, cancer stem cells, signaling pathways, etc. Nowadays, breast cancer implication and developmental study is hot topic in clinical and basic research related to multiple cells surfaces and hormone receptor like Estrogens receptor , Progesterone receptor and Human epidermal growth factor receptor-2(HER2) and major signalling pathways such as Mitogen activated protein kinase (MAPK), calcium signaling, delta-notch, wnt/β-catenine signaling etc play an important role in it. Now clinical studies show that monoclonal antibodies opposed to specific protein receptor that involved in cancer growth and improve the immortality rate for women. In this review, crosstalk on inhibit the molecular mechanisms of specific signalling pathways through suppressed the over expression of the receptors via monoclonal antibodies that involved in breast cancer. |
| Keywords: | Breast cancer, downstream signaling pathways, Monoclonal antibodies, Growth factor receptor. |
| Cite Article: | "Screening of Oncogenic Signaling Pathways and Therapeutic Application of Monoclonal Antibodies in Breast Cancer", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 3, page no.100 - 109, March-2020, Available :http://www.ijsdr.org/papers/IJSDR2003020.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2003020 Registration ID:191445 Published In: Volume 5 Issue 3, March-2020 DOI (Digital Object Identifier): Page No: 100 - 109 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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