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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Authors Name: Pandey shubham , Dwivedi Deepti , Verma Monika , Singh Mahesh
Unique Id: IJSDR1902047
Published In: Volume 4 Issue 2, February-2019
Abstract: Transdermal drug delivery systems have been used as safe and effective drug delivery devices. Their potential role in the controlled release is being globally exploited by scientists with a high rate of attainment. With oral and parenteral drug delivery systems, poor patient compliance is a frequent problem observed in daily clinical practice. Transport of drug across the skin is the best route of drug delivery because the skin is the largest human organ with a total weight of 3 kg and a surface of 1.5 -2.0 m2. But the big hurdle in transdermal delivery of the drug is the skin, the stratum corneum, the outermost envelope of the skin. Transferosomes possess an infrastructure consists of hydrophobic and hydrophilic moieties together and as a result, can accommodate drug molecules with a wide range of solubility. Transfersomes can deform and pass through a narrow constriction (from 5 to 10 times less than their own diameter) without measurable loss. Transfersomes penetrate through the pores of stratum corneum which are smaller than its size and get into the underlying viable skin in intact form due to its deformable nature. The system can be characterized by in vitro for vesicle shape and size, entrapment efficiency, the degree of deformability, number of vesicles per cubic mm. This high deformability gives better penetration of intact vesicles. They can act as a carrier for low as well as high molecular weight drugs e.g. analgesic, anesthetic, corticosteroids, sex hormones, anticancer, insulin, gap junction protein, and albumin. The present review highlights the advantages and disadvantages, formulation method, characterization, and therapeutic applications of transferases.
Keywords: Transdermal, drug delivery device, Transfersomes, Phospholipids edge activator
Cite Article: "A REVIEW ON TRANSDERMAL DRUG DELIVERY SYSTEM: TRANSFEROSOMES", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.4, Issue 2, page no.290 - 295, February-2019, Available :http://www.ijsdr.org/papers/IJSDR1902047.pdf
Downloads: 000101746
Publication Details: Published Paper ID: IJSDR1902047
Registration ID:190090
Published In: Volume 4 Issue 2, February-2019
DOI (Digital Object Identifier):
Page No: 290 - 295
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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