FORMULATION AND EVALUATION OF CURCUMIN LOADED SOLID LIPID NANOPARTICLES BY EMPLOYING GLYCERYL MONOSTEARATE
SHRUTI MADDERLA
, P.TRIPURA SUNDARI
Glycerol Monostearate (GMS), Solid lipid nanoparticles (SLNs), Hot Homogenization Method (HHM).
Curcumin was naturally occurring agent with poor solubility also with a bioavailability of 3%. It is useful in many potential pharmacological effects including anti-inflammatory, antibacterial, antioxidant and anticancer activities. It was also proved against cardiovascular disease, Alzheimer’s disease, liver problems, rheumatic arthritis, diabetics, Parkinson’s disease and neurological disorders. To enhance its solubility, permeability and bioavailability nanoparticle technology is very much useful. In the present work attempts were made to prepare the SLNs of curcumin by employing Glyceryl monostearate (GMS) as solid lipid, Tween 80and soya lecithin as hydrophilic and lipophilic surfactants respectively. The five prepared formulations were evaluated for various parameters like entrapment efficiency, In Vitro drug release, particle size, Zeta potential and SEM analysis. Among all the Preparations G3 formulation was best in terms of Drug content of 85.5%, Entrapment efficiency of 72.2%, Drug release of 64.0%, Particle size of 393.1 nm with Zeta potential of -15.1 mV and was also in accordance with particle size in nano range by SEM analysis in Hot Homogenization. The present study conclusively demonstrated that the solubility of drug was improved by entrapment of drug into solid lipid carrier which led to prolongation of drug release.
"FORMULATION AND EVALUATION OF CURCUMIN LOADED SOLID LIPID NANOPARTICLES BY EMPLOYING GLYCERYL MONOSTEARATE", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.3, Issue 11, page no.208 - 216, December-2018, Available :https://ijsdr.org/papers/IJSDR1812035.pdf
Volume 3
Issue 11,
December-2018
Pages : 208 - 216
Paper Reg. ID: IJSDR_180910
Published Paper Id: IJSDR1812035
Downloads: 000347233
Research Area: Pharmacy
Country: HYDERABAD, TELANGANA, India
ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016
An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator
Publisher: IJSDR(IJ Publication) Janvi Wave
