Oxidative Spectrophotometric Determination Of Clopidogrel In The Presence Of Aspirin Using Ceric Ammonium Nitrate (CAN)

I LAKSHMI PRASANNA , G.T. Naidu , Nuzhath Fathima , G. Abdul Huq

Spectrophotometry, Clopidogrel, Asprin, Oxidation method, CAN, Pharmaceutical Formulations

A simple, precise, accurate and versatile new spectrophotometric method is proposed for the estimation of micro determination of the drug Clopidogrel in the presence of Asprin using CAN. It is also known as Clopin-A. During the course of study, it is observed that acidic solution of the drug, when treated with CAN forms the oxidation product which is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed λmax at 300 nm. Applicability of Beer- Lamberts law showed the linearity range for Clopidogrel in the presence of Aspirin is found to be 20 μg/ml to 200 μg/ml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 2.8162x 104 lit/ mole/cm and 0.0149 μg/ ml/ cm2 respectively.

Published Paper   E-Certificate

"Oxidative Spectrophotometric Determination Of Clopidogrel In The Presence Of Aspirin Using Ceric Ammonium Nitrate (CAN)", IJSDR - International Journal of Scientific Development and Research (www.IJSDR.org), ISSN:2455-2631, Vol.3, Issue 7, page no.328 - 333, July-2018, Available :https://ijsdr.org/papers/IJSDR1807055.pdf

Volume 3 Issue 7, July-2018

Pages : 328 - 333

Paper Reg. ID: IJSDR_180557

Published Paper Id: IJSDR1807055

Downloads: 000346998

Research Area: Physics

Country: UPPAL,HYDERABAD, TELANGANA, India

Published Paper PDF: https://ijsdr.org/papers/IJSDR1807055

Published Paper URL: https://ijsdr.org/viewpaperforall?paper=IJSDR1807055

ISSN: 2455-2631 | IMPACT FACTOR: 9.15 Calculated By Google Scholar | ESTD YEAR: 2016

An International Scholarly Open Access Journal, Peer-Reviewed, Refereed Journal Impact Factor 9.15 Calculate by Google Scholar and Semantic Scholar | AI-Powered Research Tool, Multidisciplinary, Monthly, Multilanguage Journal Indexing in All Major Database & Metadata, Citation Generator

Publisher: IJSDR(IJ Publication) Janvi Wave

This work is licensed under a Creative Commons Attribution 4.0 International License and The Open Definition