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Paper Title: Oxidative Spectrophotometric Determination Of Clopidogrel In The Presence Of Aspirin Using Ceric Ammonium Nitrate (CAN)
Authors Name: I LAKSHMI PRASANNA , G.T. Naidu , Nuzhath Fathima , G. Abdul Huq
Unique Id: IJSDR1807055
Published In: Volume 3 Issue 7, July-2018
Abstract: A simple, precise, accurate and versatile new spectrophotometric method is proposed for the estimation of micro determination of the drug Clopidogrel in the presence of Asprin using CAN. It is also known as Clopin-A. During the course of study, it is observed that acidic solution of the drug, when treated with CAN forms the oxidation product which is exploited for the development of spectrophotometric method for the determination and analysis of the drug. The oxidation product showed λmax at 300 nm. Applicability of Beer- Lamberts law showed the linearity range for Clopidogrel in the presence of Aspirin is found to be 20 μg/ml to 200 μg/ml. Recovery studies gave satisfactory results indicating that none of common additives and excipients interfere the assay method. The molar absorptivity and the sandell sensitivity of the method are evaluated and the values are found to be to be 2.8162x 104 lit/ mole/cm and 0.0149 μg/ ml/ cm2 respectively.
Keywords: Spectrophotometry, Clopidogrel, Asprin, Oxidation method, CAN, Pharmaceutical Formulations
Cite Article: "Oxidative Spectrophotometric Determination Of Clopidogrel In The Presence Of Aspirin Using Ceric Ammonium Nitrate (CAN)", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.3, Issue 7, page no.328 - 333, July-2018, Available :http://www.ijsdr.org/papers/IJSDR1807055.pdf
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Publication Details: Published Paper ID: IJSDR1807055
Registration ID:180557
Published In: Volume 3 Issue 7, July-2018
DOI (Digital Object Identifier):
Page No: 328 - 333
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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