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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Formulation and Evaluation of Effervescent Floating Tablet of Cefuroxime Axetil |
| Authors Name: | Samiksha Burange , Gauri Rathod , Diksha Ghorpade , Shivani Kotamkar |
| Unique Id: | IJSDR2007095 |
| Published In: | Volume 5 Issue 7, July-2020 |
| Abstract: | Cefuroxime (Cefuroxime axetil) an oral prodrug shows a bioavailability of 30% to 40% when taken on fasting and 5% to 60% when taken after food. The cefuroxime axetil esterase can hydrolyze cefuroxime axetil to the less absorbable cefuroxime in the stomach lumen and is therefore, suspected as a possible cause of incomplete bioavailability. Which suggests an absorption mechanism through the mucosa with limited capacity. Therefore, in the present study the floating tablet of cefuroxime axetil was prepared to provide a gastro retentive system for controlled release of therapeutically active agent, cefuroxime axetil in upper part of gastro-intestinal tract in the form of floating tablet. The prepared tablet was evaluated for various parameters like hardness, weight variation, thickness, % drug content, % cumulative drug release, ANOVA. From the study it was seen that the formulation F7 shows better floating and controlled release action as compared with other formulation. Therefore it was chosen as the optimized formulation. |
| Keywords: | Cefuroxime axetil, ANOVA, Eudragit, HPMC, GRDDS, Floating Tablet. |
| Cite Article: | "Formulation and Evaluation of Effervescent Floating Tablet of Cefuroxime Axetil", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 7, page no.660 - 667, July-2020, Available :http://www.ijsdr.org/papers/IJSDR2007095.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2007095 Registration ID:192170 Published In: Volume 5 Issue 7, July-2020 DOI (Digital Object Identifier): Page No: 660 - 667 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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