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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Evaluation Of Anti-Inflammatory Activity Of Polyherbal Mixture On Indomethacin Induced IBD In Rats |
| Authors Name: | A. Manga Devi , M. Jaya Lakshmi , B. Hanuman Kishore , G. Durga Madhuri |
| Unique Id: | IJSDR2007079 |
| Published In: | Volume 5 Issue 7, July-2020 |
| Abstract: | Inflammatory bowel disease are an immune mediated chronic/relapsing disorders of the (GI)tract can be induced by indomethacin (7.5mg/kg s.c for 2 days) morphological alterations were evaluated by macroscopic scoring system and on the base of histological changes in the small intestine. It was found that the indomethacin induced severe macroscopic changes (hyperaemia, petechia, bleeding, erosions, ulcerations) and significant histological alterations in the small intestine of rats which were definitely inhibited by mesalamine (50mg/kg)given as oral dose along with the plant herbs (Withania somnifera, Azardichta indica, Momordica charantia)for 28 days with the ratios 2:2:1, 2:1:2, 2:2:2 and 4th formulation with equal ratio were taken to complete acute toxicity studies. By the toxicity studies result in two different formulations with the ratios 2:2:1, 2:1:2 evaluated against Indomethacin induced IBD. After the study period blood and organs were collected for biochemical analysis and histopathological studies, the above findings prove that, Azadirachta indica, Momordica charantia, Withania somnifera mixtures has protective effect against indomethacin-induced inflammatory bowel disease. |
| Keywords: | Azadirachta indica, Momordica charantia, Withania somnifera, indomethacin, IBD |
| Cite Article: | "Evaluation Of Anti-Inflammatory Activity Of Polyherbal Mixture On Indomethacin Induced IBD In Rats", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 7, page no.571 - 576, July-2020, Available :http://www.ijsdr.org/papers/IJSDR2007079.pdf |
| Downloads: | 000336850 |
| Publication Details: | Published Paper ID: IJSDR2007079 Registration ID:192148 Published In: Volume 5 Issue 7, July-2020 DOI (Digital Object Identifier): Page No: 571 - 576 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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