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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Paper Title: METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LUMACAFTOR AND IVACAFTOR BY RP-HPLC
Authors Name: Gangi.Sireesha , Dr.D.Narendra , M.Lakshmi prasanna , M.Lakshmi priya
Unique Id: IJSDR2007077
Published In: Volume 5 Issue 7, July-2020
Abstract: A simple, Accurate, precise method was developed for the simultaneous estimation of the Ivacaftor and Lumacaftor in Tablet dosage form. Chromatogram was run throughPhenominex (4.6 x 250mm, 5m), Mobile phase containing Buffer 40% buffer 60% Acetonitrile taken in the ratio 40:60 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.1N H3PO4. Temperature was maintained at 30°C. Optimized wavelength selected was 265 nm. Retention time of Ivacaftor and Lumacaftorwere found to be 6.329 min and 2.857min. %RSD of the Ivacaftor and Lumacaftor were and found to be 0.8 and 0.8 respectively. %Recovery was obtained as 100.13% and 100.53% for Ivacaftor and Lumacaftor respectively. LOD, LOQ values obtained from regression equations of Ivacaftor and Lumacaftor were 3.00, 10.00 and 3.02, 9.98 respectively. Regression equation of Ivacaftor is y = 27194x + 45038and y = 332.76x + 31993 of Lumacaftor. Retention times were decreased and run time was decreased, so the method developed was simple and economical that can be adopted in regular Quality control test in Industries.
Keywords: LUMACAFTOR ,IVACAFTOR,RP-HPLC
Cite Article: "METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMATION OF LUMACAFTOR AND IVACAFTOR BY RP-HPLC", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 7, page no.516 - 560, July-2020, Available :http://www.ijsdr.org/papers/IJSDR2007077.pdf
Downloads: 000336257
Publication Details: Published Paper ID: IJSDR2007077
Registration ID:192147
Published In: Volume 5 Issue 7, July-2020
DOI (Digital Object Identifier):
Page No: 516 - 560
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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