INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
The purpose of this research was to develop a matrix-type transdermal therapeutic system containing drug Bifonazole, Pressure Sensitive Adhesive (PSA) like acrylic adhesive by the solvent evaporation technique. Different concentrations of Labrasol, oleic acid and triacetin were used to enhance the transdermal permeation of Bifonazole Polyethylene monolayer film as a backing membrane and Silicone coated polyester film as a release liner preferred in preparation of transdermal patches. Formulated transdermal patches were physically evaluated with regard to percentage moisture absorption, thickness, weight variation, drug content, tensile strength, % elongation, folding endurance. All prepared formulations indicated good physical stability. In vitro skin permeation studies of formulations were performed by using Franz diffusion cells. Formulation containing 5% drug, 85% adhesive solution and 10% triacetin as permeation enhancer showed best in vitro skin permeation through human cadaver skin as compared to all other formulations. The results rate was found to follow zero order kinetics.
"Preparation and evaluation of Transdermal patches of Bifonazole", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 7, page no.467 - 470, July-2020, Available :http://www.ijsdr.org/papers/IJSDR2007066.pdf
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Publication Details:
Published Paper ID: IJSDR2007066
Registration ID:192139
Published In: Volume 5 Issue 7, July-2020
DOI (Digital Object Identifier):
Page No: 467 - 470
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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