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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Method Development & Validation for Simultaneous Estimation of Emtricitabine, Rilpivirine & Tenofovir Alafenamide by RP-HPLC Method |
| Authors Name: | Karumudi Vasudha Reddy , Dr. Devanaboyina Narendra , P. Venkata Kishore , Gadi Vijaya Lakshmi |
| Unique Id: | IJSDR2007010 |
| Published In: | Volume 5 Issue 7, July-2020 |
| Abstract: | A simple, accurate, precise method was developed for the simultaneous estimation of the Emtricitabine, Rilpivirine and Tenofovir Alafenamide by rp-hplc method in bulk and tablet dosage form. Chromatogram was run through Kromasil C18 250x4.6mm, 5m. Mobile phase containing Kh2po4 and Acetonitrile in the ratio of 65:35 v/v was pumped through column at a flow rate of 1ml/min. Temperature was maintained at 30°C. Optimized wavelength for Emtricitabine, Rilpivirine and Tenofovir Alafenamide was 270.00 nm. Retention time of Emtricitabine, Rilpivirine and Tenofovir Alafenamide were found to be 2.212 min, 2.765min and 3.274min. %RSD of system precision for Emtricitabine, Rilpivirine and Tenofovir Alafenamide were and found to be 0.6, 0.8 and 0.5 respectively. %RSD of method precision for Emtricitabine, Rilpivirine and Tenofovir Alafenamide were and found to be 0.5, 0.9 and 0.7 respectively. % recovery was obtained as 99.79%, 100.53% and 99.71% for Emtricitabine, Rilpivirine and Tenofovir Alafenamide respectively. LOD values are obtained from regression equations of Emtricitabine, Rilpivirine and Tenofovir Alafenamide were 1.59ppm, 0.15ppm, 0.16ppm and LOQ values are obtained from regression equations of Emtricitabine, Rilpivirine and Tenofovir Alafenamide were 4.81ppm, 0.45ppm, and 0.46 ppm respectively. Regression equation of Emtricitabine was y = 11254x + 11045. Rilpivirine was y = 9026.8x + 1154.8. and of Tenofovir Alafenamide was y = 16962x + 1751.2. Retention times are decreased so the method developed was simple and economical that can be adopted in regular Quality control test in Industries. |
| Keywords: | Emtricitabine. Rilpivirine, Tenofovir Alafenamide, RP-HPLC |
| Cite Article: | "Method Development & Validation for Simultaneous Estimation of Emtricitabine, Rilpivirine & Tenofovir Alafenamide by RP-HPLC Method", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 7, page no.95 - 102, July-2020, Available :http://www.ijsdr.org/papers/IJSDR2007010.pdf |
| Downloads: | 000337071 |
| Publication Details: | Published Paper ID: IJSDR2007010 Registration ID:192053 Published In: Volume 5 Issue 7, July-2020 DOI (Digital Object Identifier): Page No: 95 - 102 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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