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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH
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ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
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Paper Title: METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMSTION OF EMTRICITABINE AND TENOFOVIR BY RP-HPLC METHOD
Authors Name: Gangi Sireesha , M.Lakshmi Priya , P. Mohan Vikas
Unique Id: IJSDR2007004
Published In: Volume 5 Issue 7, July-2020
Abstract: A simple, Accurate, precise method was developed for the simultaneous estimation of the Emtricitabine and Tenofovir in Tablet dosage form. Chromatogram was run through Inspire C 18 (4.6 x 150mm, 5.0m), Mobile phase containing 30% buffer: 70% Methanol taken in the ratio 30:70 was pumped through column at a flow rate of 1 ml/min. Buffer used in this method was 0.1N H3PO4. Temperature was maintained at 30°C. Optimized wavelength selected was 272 nm. The linearity of Emtricitabine and Tenofovir DF was found to be linear with a correlation coefficient of 0.999 and 0.999. The acceptance criteria of precision is RSD should be not more than 2.0% and the method show precision 0.22 and 0.5 for Emtricitabine and Tenofovir DF. The acceptance criteria of intermediate precision is RSD should be not more than 2.0% and the method show precision 0.6 and 0.69 for Emtricitabine and Tenofovir DF. The accuracy limit is the percentage recovery should be in the range of 97.0% - 103.0%. The total recovery was found to be 100.35% and 100.24% for Emtricitabine and Tenofovir DF. The LOD and LOQ for Tenofovir DF was found to be 2.98 and 9.98 and LOD and LOQ for Emtricitabine was found to be 2.96 and 9.96.
Keywords: Emtricitabine, Tenofovir , RP-HPLC
Cite Article: "METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS ESTIMSTION OF EMTRICITABINE AND TENOFOVIR BY RP-HPLC METHOD", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 7, page no.21 - 60, July-2020, Available :http://www.ijsdr.org/papers/IJSDR2007004.pdf
Downloads: 000336256
Publication Details: Published Paper ID: IJSDR2007004
Registration ID:191995
Published In: Volume 5 Issue 7, July-2020
DOI (Digital Object Identifier):
Page No: 21 - 60
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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