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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | A Review: CRISPR/Cas9 - Mediated Genome Editing in Hematopoietic Stem and Progenitor Cells (HSPCs) and Their Applications on Hematological Disorders |
| Authors Name: | Lakshmi Kumari , Suryaharitha S. , Shivani , Vinod Kumar Gupta |
| Unique Id: | IJSDR2003035 |
| Published In: | Volume 5 Issue 3, March-2020 |
| Abstract: | Hematopoietic stem and progenitor cells (HSPCs) have great therapeutic important in the medical science due to its ability to both self-renew and differentiate. A genetically modified HSPCs could result in correction of the entire hematopoietic system in patients with various hematological disorders, due to this unique properties. One of the evolutionary discovery in the field of biology is the ability to altered and modify the functional output of genome. Zinc-finger nuclease (ZFNs) and transcriptional activator-like effector nucleases (TALENs) are the genome editing technologies used at both the basic and clinical level from the past decades. But after knowing many obstacles are associated with this technologies, scientists leads to a new discovery of a advance technology in the field of genetic engineering and this tool was known as clustered regularly interspaced short palindromic repeats (CRISPR)- associated protein 9 (Cas9) system. In this review, we describe the mechanism of CRISPR/Cas9 gene editing in HSPCs and their applications in various haematological disorders. In addition, we discuss the challenges and future perspectives regarding the use of CRISPR/Cas9 as an important technology in the stem cells research. |
| Keywords: | Hematopoietic stem and progenitor cells, CRISPR-Cas9, ZFNs, TALENs, hematological disorders, gene editing. |
| Cite Article: | "A Review: CRISPR/Cas9 - Mediated Genome Editing in Hematopoietic Stem and Progenitor Cells (HSPCs) and Their Applications on Hematological Disorders", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.5, Issue 3, page no.181 - 192, March-2020, Available :http://www.ijsdr.org/papers/IJSDR2003035.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR2003035 Registration ID:191475 Published In: Volume 5 Issue 3, March-2020 DOI (Digital Object Identifier): Page No: 181 - 192 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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