INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016
open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15
ATT(ANTI TUBERCULOSIS TREATMENT) INDUCED ERYTHRODERMA. Vageeshwari Devuni. Pharm.D CMR COLLEGE OF PHARMACY. Kandlakoya, Medchal road, Hyderabad(501401). ABSTRACT: Tuberculosis(TB) is a common infectious disease in the developing countries. Cutaneous adverse drug reactions(CADR) with antitubercular treatment(ATT) can make further management of TB Challenging. Isoniazid is the first-line antitubercular drug par excellence and an essential component of all antitubercular regimens unless the patient is intolerant to it, or bacilli show resistance. Among antitubercular drugs, exfoliative dermatitis has been reported with rifampicin, isoniazid, ethambutol, pyrazinamide, streptomycin, PAS either singly or combination of two drugs. The most common ADE while on ATT, namely drug induced hepatitis, skin rash. Various causes of erythroderma in adults include pre-existing eczema, psoriasis, lymphoma, leukemia, and drugs such as phenylbutazone, hydantoin derivatives, carbamazepine, sulfonamides, penicillins, cimetidine, diltiazen, dapsone, allopurinol, gold salts, and lithium. Early recognition, prompt withdrawal of antitubercular therapy and institution of steroids, if reaction is severe, are cornerstones of its management. It is important to recognize the CADRs to ATT so that severe and potentially life-threatening adverse reaction can be identified and managed early. It is equally important to continue ATT in minor CADRs so that patients suffering from TB can be cured and rendered non-infectious as early as possible from uninterrupted ATT along with prevention of development of drug resistance.
Keywords:
Tuberculosis, Antitubercular treatment, cutaneous drug reactions, drug resistance, exfoliative dermatitis, skin rash, rifampicin
Cite Article:
"ATT(Anti tuberculosis treatment) induced Erythroderma", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.4, Issue 6, page no.273 - 275, June-2019, Available :http://www.ijsdr.org/papers/IJSDR1906051.pdf
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Publication Details:
Published Paper ID: IJSDR1906051
Registration ID:190708
Published In: Volume 4 Issue 6, June-2019
DOI (Digital Object Identifier):
Page No: 273 - 275
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631
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