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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | FORMULATION AND EVALUATION OF ALCOHOL RESISTANT MATRIX TABLETS OF QUETIAPINE FUMARATE BY USING VARIOUS POLYMERS:HPMC K 15M AND ETHYL CELLULOSE |
| Authors Name: | S. Ramyasri , Dr. P. Tripura sundari |
| Unique Id: | IJSDR1906040 |
| Published In: | Volume 4 Issue 6, June-2019 |
| Abstract: | Objective: The present work is focused on the Formulation and Evaluation of Alcohol Resistant Dosage Forms of Quetiapine fumarate by various polymers. METHOD: Oral controlled matrix tablet formulations of Quetiapine fumarate were prepared by wet granulation method. Matrix tablets provide specific advantages in controlling the drug release rate from the dosage form mainly by the type and proportion of polymers used in the preparation. The major drawback for these system is dose dumping which is prominent in presence of alcohol. In the present study attempt was made to prepare alcohol resistant tablet formulations of Quetiapine fumarate. Quetiapine fumarate is used as a model drug which is an anti- psychotic agent. Various polymers like Ethylcellulose, HPMC K50M, Xanthan gum were used for preparing the matrix tablets. The prepared matrix tablets were studied for drug release studies at various concentration of alcohol. RESULTS AND DISCUSSION: The invitro drug release studies were carried out in phosphate buffer as well as phosphate buffer containing 5%, 10% and 15% alcohol. Drug release studies from these matrix tablets was by non – fickian diffusion and was comparable with that of marketed preparations. The polymer combination was also found to be an efficient alcohol resisting agent and the matrix tablets of Quetiapine fumarate had shown resistance to alcohol induced dose dumping. |
| Keywords: | Quetiapine fumarate, HPMC K50M, Ethylcellulose, Xanthan gum, Alcohol resistance, Matrix tablets. |
| Cite Article: | "FORMULATION AND EVALUATION OF ALCOHOL RESISTANT MATRIX TABLETS OF QUETIAPINE FUMARATE BY USING VARIOUS POLYMERS:HPMC K 15M AND ETHYL CELLULOSE", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.4, Issue 6, page no.202 - 220, June-2019, Available :http://www.ijsdr.org/papers/IJSDR1906040.pdf |
| Downloads: | 000337070 |
| Publication Details: | Published Paper ID: IJSDR1906040 Registration ID:190700 Published In: Volume 4 Issue 6, June-2019 DOI (Digital Object Identifier): Page No: 202 - 220 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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