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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS DETERMINATION OF METFORMIN AND SAXAGLIPTIN BY RP-HPLC |
| Authors Name: | Bangaruthalli Jagirapu , Swathi.T , Kusumapriya.N , N. Hemalatha , Sailaja.R |
| Unique Id: | IJSDR1901018 |
| Published In: | Volume 4 Issue 1, January-2019 |
| Abstract: | A simple, sensitive, stability indicating and precise HPLC method for estimation of Saxagliptin and Metformin tablets has been developed and validated for determination in commercial dosage forms. The compound were well separated isocratically on a Agila C-18 (ODS) RP-Column, (25cm x 4.6mm, 5μ) using a mobile phase consisting of Acetate buffer : Acetonitrile : Methanol in the ratio of 70: 20 :10, at a flow rate of 1ml/min with UV detection at 225 nm. The retention time of Metformin at 3.539 min and Saxagliptin peak was at 6.005 mins and . The method was linear over the concentration range for Saxagliptin 10-50μg/ml and for Metformin 5-25 μg/ml. The recoveries of Metformin and Saxagliptin were found to be 100.32% and 99.9 respectively. The validation of method was carried out utilizing ICH-guidelines. The described HPLC method was successfully employed for the analysis of pharmaceutical formulations containing combined dosage form. |
| Keywords: | Metformine, Saxagliptine, RP-HPLC, ICH-guidelines, validation |
| Cite Article: | "METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS DETERMINATION OF METFORMIN AND SAXAGLIPTIN BY RP-HPLC", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.4, Issue 1, page no.108 - 113, January-2019, Available :http://www.ijsdr.org/papers/IJSDR1901018.pdf |
| Downloads: | 000337067 |
| Publication Details: | Published Paper ID: IJSDR1901018 Registration ID:190008 Published In: Volume 4 Issue 1, January-2019 DOI (Digital Object Identifier): Page No: 108 - 113 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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