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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | Isolation, Purification Of Ocimum Basilicum And Carica Papaya Seed Mucilages & Preparation Of Valsartan Oro Dispersable Tablets By Using Nturalasuperdisintegrants |
| Authors Name: | M.LAKSHMI PRASANNA , P.SHAILAJA , N.V.V.JAGAN MOHAN REDDY , D,NARENDRA |
| Unique Id: | IJSDR1901010 |
| Published In: | Volume 4 Issue 1, January-2019 |
| Abstract: | Orodispersible tablets (ODTs), have the unique property of disintegrating in the mouth in seconds without chewing and the need of water. The purpose of this investigation was to develop mouth dissolving tablets of Valsartan using Carica Papaya seed mucilage and Ocimum bacillum seed mucilage as a novel superdisintegrant. The present study demonstrated potentials for rapid absorption, improved bioavailability, effective therapy and patient compliance. The rationale of the study was to formulate orodispersible tablets of Valsartan for improving its poor oral bioavailability and with the aim of alleviating administration to patients facing problems with swallowing.. Formulation F5& F11 was selected as optimized batch containing Ocimum basilicum seed mucilage & Carica papaya seed mucilage as the superdisintegrant in 10% concentration. The mechanism involved in tablet disintegration is swelling action helps in the faster disintegration of tablets. It has less disintegration time of around 2’36”. The dissolution study was carried out and 99.2% & 99.0 of drug release was occurring within 10min. The stability study of optimized batch was carried out at400C/75%RH. The tabletswere found to be stable at such condition and there is slight increase in the moisture content.The promising formulations was found to be stable during the stability studies conducted as per ICH guidelines, as it showed no significant changes in the physicochemical properties, disintegration time and in-vitro drug release. |
| Keywords: | orodispesable, ocimummucilage, papaya mucilage,MCC,valsartan |
| Cite Article: | "Isolation, Purification Of Ocimum Basilicum And Carica Papaya Seed Mucilages & Preparation Of Valsartan Oro Dispersable Tablets By Using Nturalasuperdisintegrants", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.4, Issue 1, page no.41 - 48, January-2019, Available :http://www.ijsdr.org/papers/IJSDR1901010.pdf |
| Downloads: | 000337078 |
| Publication Details: | Published Paper ID: IJSDR1901010 Registration ID:190004 Published In: Volume 4 Issue 1, January-2019 DOI (Digital Object Identifier): Page No: 41 - 48 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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