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INTERNATIONAL JOURNAL OF SCIENTIFIC DEVELOPMENT AND RESEARCH International Peer Reviewed & Refereed Journals, Open Access Journal ISSN Approved Journal No: 2455-2631 | Impact factor: 8.15 | ESTD Year: 2016 open access , Peer-reviewed, and Refereed Journals, Impact factor 8.15 |
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| Paper Title: | FORMULATION AND EVALUATION OF CURCUMIN LOADED SOLID LIPID NANOPARTICLES BY EMPLOYING GLYCERYL MONOSTEARATE |
| Authors Name: | SHRUTI MADDERLA , P.TRIPURA SUNDARI |
| Unique Id: | IJSDR1812035 |
| Published In: | Volume 3 Issue 11, December-2018 |
| Abstract: | Curcumin was naturally occurring agent with poor solubility also with a bioavailability of 3%. It is useful in many potential pharmacological effects including anti-inflammatory, antibacterial, antioxidant and anticancer activities. It was also proved against cardiovascular disease, Alzheimer’s disease, liver problems, rheumatic arthritis, diabetics, Parkinson’s disease and neurological disorders. To enhance its solubility, permeability and bioavailability nanoparticle technology is very much useful. In the present work attempts were made to prepare the SLNs of curcumin by employing Glyceryl monostearate (GMS) as solid lipid, Tween 80and soya lecithin as hydrophilic and lipophilic surfactants respectively. The five prepared formulations were evaluated for various parameters like entrapment efficiency, In Vitro drug release, particle size, Zeta potential and SEM analysis. Among all the Preparations G3 formulation was best in terms of Drug content of 85.5%, Entrapment efficiency of 72.2%, Drug release of 64.0%, Particle size of 393.1 nm with Zeta potential of -15.1 mV and was also in accordance with particle size in nano range by SEM analysis in Hot Homogenization. The present study conclusively demonstrated that the solubility of drug was improved by entrapment of drug into solid lipid carrier which led to prolongation of drug release. |
| Keywords: | Glycerol Monostearate (GMS), Solid lipid nanoparticles (SLNs), Hot Homogenization Method (HHM). |
| Cite Article: | "FORMULATION AND EVALUATION OF CURCUMIN LOADED SOLID LIPID NANOPARTICLES BY EMPLOYING GLYCERYL MONOSTEARATE", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.3, Issue 11, page no.208 - 216, December-2018, Available :http://www.ijsdr.org/papers/IJSDR1812035.pdf |
| Downloads: | 000337064 |
| Publication Details: | Published Paper ID: IJSDR1812035 Registration ID:180910 Published In: Volume 3 Issue 11, December-2018 DOI (Digital Object Identifier): Page No: 208 - 216 Publisher: IJSDR | www.ijsdr.org ISSN Number: 2455-2631 |
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