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International Journal of Scientific Development and Research - IJSDR
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Issue: December 2019

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Paper Title: Bioinformatics Analysis of BDNF-TrkB Interactions to Identify Nerve growth factor and Neurotrophin-3 as Agonist of TrkB Helpful in Cell Survival Signaling Pathways of Type 2 Diabetic Retinopathy
Authors Name: Vaibhav Singh , Anjali Dwivedi , Archana Tiwari
Unique Id: IJSDR1805098
Published In: Volume 3 Issue 5, May-2018
Abstract: Type 2 Diabetic Retinopathy is a communal cause of visual damage in the world and it is actually blinding complication of diabetes that damages the eye's retina. Type 2 Diabetic retinopathy is a complication of diabetes that distresses the blood vessels of the retina. Growth of new blood vessels, known as proliferative retinopathy, may lead to blindness through hemorrhage and scarring. A worsening of retinal blood vessels producing loss of blood vessels and leakage into the retina is known as maculopathy and leads to visual impairment and may progress to blindness. Brain-derived neurotrophic factor (BDNF) activates the receptor tropomyosin-related kinase B (TrkB) with high potency and specificity, promoting neuronal survival, differentiation, and synaptic function. In this research, NTF3, NGF interactions with TrkB has been done as NTF3 and NGF acts as agonist for TrkB, which may help in retinal cell survival which would in turn help in controlling Type 2 Diabetic Retinopathy.
Keywords: Type 2 Diabetic retinopathy, Brain-derived neurotrophic factor, Tropomyosin-related kinase B, Nerve growth factor, Neurotrophin-3
Cite Article: "Bioinformatics Analysis of BDNF-TrkB Interactions to Identify Nerve growth factor and Neurotrophin-3 as Agonist of TrkB Helpful in Cell Survival Signaling Pathways of Type 2 Diabetic Retinopathy", International Journal of Science & Engineering Development Research (www.ijsdr.org), ISSN:2455-2631, Vol.3, Issue 5, page no.645 - 652, May-2018, Available :http://www.ijsdr.org/papers/IJSDR1805098.pdf
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Publication Details: Published Paper ID: IJSDR1805098
Registration ID:180350
Published In: Volume 3 Issue 5, May-2018
DOI (Digital Object Identifier):
Page No: 645 - 652
Publisher: IJSDR | www.ijsdr.org
ISSN Number: 2455-2631

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